PD SENIOR SCIENTIST - DOWNSTREAM
Company: Cytovance Biologics
Location: Oklahoma City
Posted on: August 7, 2022
Job Description:
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for an accommodation or an alternative application process. PD
SENIOR SCIENTIST - DOWNSTREAM Full Time Regular R&D Oklahoma
City, OK, US 2 days ago Requisition ID: 1370 An Energetic Community
- Headquartered in Downtown Oklahoma City, offering everything you
look for in a modern metropolitan community. An abundance of arts,
quality health care, excellence in education and more. It is a
distinctly livable city where you can chase your dreams and still
enjoy a rich quality of life. Visit abetterlifeokc.com A
Competitive Benefit Package - Cytovance offers a competitive 401k
match, medical benefits, Professional Development and Tuition
Reimbursement, Paid Holidays, and a generous amount of paid time
away from your job. HOW WILL YOU MAKE AN IMPACT? The Process
Development Sr. Scientist leads multiple client projects to meet
timeline, budget and scope commitments and has a good working
knowledge of protein purification pertaining to the drug
development process and knowledge of relevant business elements.
The Senior Scientist keeps an up-to-date awareness of advances in
multiple technological and scientific areas and has strong academic
and industrial contacts. Supervision or mentoring other colleagues
providing guidance, coaching and career development support is
required. Essential Duties and Responsibilities: -
- Will be responsible for leading multiple client projects in
parallel for protein purification.
- Work with R&D Directors and senior leadership on developing
downstream purification processes for client projects along with
innovative internal experiments.
- Serve as a point-of-contact and subject matter expert for
chromatography method design, application and troubleshooting,
buffer formulation, chromatography column packing, and TFF
methods.
- Represent Cytovance and downstream technical area in client
team meetings.
- Align client and business goals to enable both client and
Cytovance success
- Supervise and perform downstream development
- Transfer downstream methods from R&D Services to the
Cytovance MST group for transfer of process to manufacturing.
- Draft and review Standard Operating Procedures (SOP's)
- Draft and review Downstream Protocols, Batch Records, Slide
Deck Data Summaries and Reports.
- Support other Downstream Scientists or Analysts by assisting in
DSP troubleshooting measures and cross-review of results and
notebooks
- Support additional R&D Services teams (cell-line
development, upstream process development, and purification
development) by generation, review, and/or interpretation of DSP
results
- Support Manufacturing groups be leveraging protein purification
expertise to support investigations and/or generation, review, and
interpretation of purification results
- Operate, maintain, and qualify (I/O/PQ) laboratory equipment
and software as required
- Specify, source, and assess new DSP technologies
- Perform data acquisition, reduction and evaluation
- Specify and source new downstream purification equipment to
expand the purification capabilities of the downstream development
laboratory
- Train others on purification techniques
- Mentor and teach others on purification theory and
application
- Serve as a liaison with purification subcontractors
- Supervision of direct reports will be required
- Stay current with all training requirements. -
- Follow procedures reliably and consistently.
- Establish good working relationships with peers and other
colleagues.
- Display a positive attitude and good flexibility.
- Proactively ensure good lab hygiene is being practiced.
- Apply technical and scientific knowledge to the overall
direction of projects. Enable Cytovance to be using the most
advance technology available. Acts as a scientific resource across
disciplines.
- Make decisions that consistently require developing new options
to solve complex problems.
- Use a high level of scientific judgment to adapt and/or create
standard methods and techniques by applying breadth of knowledge
and prior work experience.
- Work is performed under minimal supervision. Exercise
considerable latitude in determining objectives of
assignments.
- Identify and develop scientific strategies to support mid-term
to long-term goals operational goals. -
- Represent technological areas and Cytovance's business
perspectives at client project team meetings -
- Exemplify sound supervisory and training skills and take
personal responsibility for the development of direct reports. -
Job Requirements:
- Ph.D., preferred in biochemistry or related science, with a
combination of - ---4 -years of laboratory experience that may be a
combination of Post -Doctoral, Academic or Industrial settings
-
- MS, in biochemistry or related science, with a minimum of 10
years directly related experience in protein purification -
- Has extensive knowledge of protein purification procedures
specifically for biopharmaceuticals
- Has direct experience and training in chromatography method
design, application and troubleshooting (affinity, ion exchange and
HIC), TFF (flat cassette, hollow fiber), buffer formulation and
chromatography column packing procedures.
- Has broad knowledge of principles, concepts, and practices with
a range of analytical techniques including ELISA, HPLC, enzymatic,
and electrophoresis (SDS-PAGE, Western blots, IEF, & CE)
procedures
- Good working knowledge of scientific and technologic
disciplines within pharmaceutical sciences
- Good working knowledge of regulatory agencies and guidance
documents governing GMP manufacturing such as ICH, FDA, and
EMA.
- Able to communicate technical details of projects and project
strategy to clients and Cytovance client team members
- Recommends and implements unique approaches to problem
solving
- Demonstrates good strategic project prioritization skills
working in a multi-project environment
- Critically evaluates information from a wide range of sources
and makes clear recommendations
- Able to work in a semi-independent manner and exercise good
judgment based on experimental data -
- Strong written and oral communication skills -
- Able to read, analyze, and interpret common scientific and
technical journals, financial reports, and legal documents.
- Able to respond to common inquiries or complaints from
customers, regulatory agencies, or members of the business
community.
- Able to write speeches and articles for publication that
conform to prescribed style and format.
- Able to effectively present information to top management,
public groups, and/or boards of directors.
- Able to define problems, collect data, establish facts, and
draw valid conclusions. -
- Able to interpret an extensive variety of technical
instructions in mathematical or diagram form and deal with several
abstract and concrete variables. Physical Demands: While performing
the duties of this Job, the employee is regularly required to talk
or hear. The employee is frequently required to stand and sit. The
employee is occasionally required to walk; use hands to finger,
handle, or feel; reach with hands and arms; climb or balance and
stoop, kneel, crouch, or crawl. The employee must occasionally lift
and/or move up to 25 pounds. While performing the duties of this
Job, the employee is occasionally exposed to fumes or airborne
particles and toxic or caustic chemicals consistent with a lab
environment. The noise level in the work environment is usually
moderate. Cytovance Biologics acknowledges that Providers may be a
valuable resource for identifying and recruiting Candidates for
employment. However, we require that all Recruiters engage directly
with Cytovance Biologic's Human Resource Team and comply with
Cytovance Biologic's requirements prior to transmitting any
Resumes/CV's or introducing any Candidates to Cytovance Biologics.
Cytovance Biologic's Human Resource Team is the only function
within the Company that can enter contractual relationships with
external Recruiters and Recruiting Agencies. We are an Equal
Opportunity Employer and do not discriminate against any employee
or applicant for employment because of race, color, sex, age,
national origin, religion, sexual orientation, gender identity,
status as a veteran, and basis of disability or any other federal,
state or local protected class. -
Keywords: Cytovance Biologics, Oklahoma City , PD SENIOR SCIENTIST - DOWNSTREAM, Other , Oklahoma City, Oklahoma
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