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Senior Scientist, Viral Vector Cell Line Development

Company: Barrington James
Location: Oklahoma City
Posted on: May 15, 2022

Job Description:

My client's mission is to radically advance humankind's ability to design living systems. They're developing a mammalian platform--from cells to software--to enable biotechnologies with outsized impact, with an initial focus on gene therapies, cell therapies, and protein therapeutics.

The ideal candidate will have a proven track record performing AAV and/or lentiviral vector stable producer cell line development in an industry setting. They will be a technical leader on our team, participating in the creation of stable producer cell lines for AAV and/or lentiviral vectors, designing complex experimental approaches to improve our workflows and systems, coordinating project efforts, and mentoring aspiring scientists. They will also work closely with the synthetic biology and process development teams. This is a unique opportunity to work at a nimble, forward-thinking synthetic biology start-up and help build the future of biological engineering.

Key Responsibilities:
- Perform AAV and/or lentiviral vector stable producer cell line development processes including transfection, cloning, characterization, and cell banking using state-of-the-art equipment
- Drive innovation through the development of novel workflows and applications
- Support research projects to develop viral vector therapeutics with enhanced quality attributes such as empty/full ratio, potency, and/or cell targeting
- Identify emerging practices for viral vector producer cell line development manufacturing to shape scientific strategies
- Work effectively as part of a cross-functional team in support of a synthetic biology design platform
- Design experiments, analyze data, troubleshoot, and maintain detailed records
- Represent the cell line development function on project teams, making decisions for cell line activities and effectively communicating results, progress and plans
- Experience in developing and optimizing scalable viral or vector-based vaccine processes including knowledge of upstream process development scale-up/scale-down, bioreactor set-up, operation and control strategies and aseptic bioprocessing.

- Ph.D. in Biological Engineering, Virology, Cell Biology, Molecular Biology, or a related field
- 2+ years of hands-on experience in AAV and/or lentiviral vector producer cell line development including transfection, cloning, characterization, and cell banking required
- Knowledge in viral vector design, analytical characterization, and process development required
- Experience performing viral transductions, flow cytometry, and quantitative gene expression analyses (ddPCR or qPCR) required
- Experience with viral genome engineering, and/or host cell genome engineering related to virus production or producer cell line technologies is highly desired
- Ability to work with global customer base supporting viral vector cell line development with molecules ranging with a high degree of complexity required
- Strong written and verbal communication skills required

My client is fuelled by a vision to transform biological engineering into a fully-fledged engineering discipline. Should you join their team, you will grow with a constantly evolving organization and push the frontiers of synthetic biology. Company culture is key, their culture of recombination; they believe that their mission can only be achieved by bringing together a diverse team with a mixture of backgrounds and perspectives.

Keywords: Barrington James, Oklahoma City , Senior Scientist, Viral Vector Cell Line Development, Other , Oklahoma City, Oklahoma

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